Open AccessOx-LDL-Induced MicroRNA-155 Promotes Autophagy in Human Endothelial Cells via Repressing the Rheb/ mTOR Pathway
Author(s) -
Jian Lv,
Lixia Yang,
R. S. Guo,
Yankun Shi,
Ziwei Zhang,
Jinshan Ye
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000481875
Subject(s) - rheb , autophagy , microrna , microbiology and biotechnology , pi3k/akt/mtor pathway , biology , viability assay , apoptosis , signal transduction , chemistry , cancer research , biochemistry , gene , mtorc1
Autophagy, an evolutionary conserved biological process, is activated in cells to cope with various types of stress. MicroRNAs control several activities related to autophagy. However, the role of autophagy-related microRNAs during atherosclerosis is far from known. MicroRNA-155 was identified to be a crucial regulator of atherosclerosis. The objectives of the study were to analyze the effect of microRNA-155 on autophagic signaling and explore its mechanism in human endothelial cells under ox-LDL stress.