Ox-LDL-Induced MicroRNA-155 Promotes Autophagy in Human Endothelial Cells via Repressing the Rheb/ mTOR Pathway | Zendy

LV Jin-lin | Zendy; Lixia Yang | Zendy; Ruiwei Guo | Zendy; Yan-Kun Shi | Zendy; Ziwei Zhang | Zendy; Jinshan Ye | Zendy

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Ox-LDL-Induced MicroRNA-155 Promotes Autophagy in Human Endothelial Cells via Repressing the Rheb/ mTOR Pathway

Author(s) -

LV Jin-lin,

Lixia Yang,

Ruiwei Guo,

Yan-Kun Shi,

Ziwei Zhang,

Jinshan Ye

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000481875

Subject(s) - rheb , autophagy , microrna , microbiology and biotechnology , pi3k/akt/mtor pathway , biology , viability assay , apoptosis , signal transduction , chemistry , cancer research , biochemistry , gene , mtorc1

Autophagy, an evolutionary conserved biological process, is activated in cells to cope with various types of stress. MicroRNAs control several activities related to autophagy. However, the role of autophagy-related microRNAs during atherosclerosis is far from known. MicroRNA-155 was identified to be a crucial regulator of atherosclerosis. The objectives of the study were to analyze the effect of microRNA-155 on autophagic signaling and explore its mechanism in human endothelial cells under ox-LDL stress.

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