Open AccessPicrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production
Author(s) -
Lingbo Kong,
Biao Wang,
Xiaobin Yang,
Hua Guo,
Ke Zhang,
Ziqi Zhu,
Jijun Liu,
Dingjun Hao
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000481874
Subject(s) - osteoclast , rankl , chemistry , bone resorption , microbiology and biotechnology , osteoblast , multinucleate , signal transduction , acid phosphatase , endocrinology , biochemistry , receptor , biology , activator (genetics) , in vitro , enzyme
Osteoporosis is a metabolic bone disorder that tortures about millions of people worldwide. Recent study demonstrated agents derived from picrasma quassioides is a promising drug for targets multiple signaling pathways. However its potential in treatment of bone loss has not been fully understood.