Open AccessIn vivo Effects of Repeated Thyronamine Administration in Male C57BL/6J Mice
Author(s) -
Lisbeth Harder,
Nancy Schanze,
Assel Sarsenbayeva,
Franziska Kugel,
Josef Köhrle,
Lutz Schomburg,
Jens Mittag,
Carolin S. Hoefig
Publication year - 2017
Publication title -
european thyroid journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.23
H-Index - 10
eISSN - 2235-0802
pISSN - 2235-0640
DOI - 10.1159/000481856
Subject(s) - endocrinology , medicine , in vivo , brown adipose tissue , thermoregulation , thermogenesis , adipose tissue , metabolism , hormone , heart rate , kidney , glycogen , cardiac function curve , thyroid , blood pressure , biology , heart failure , microbiology and biotechnology
Thyronamines are decarboxylated and deiodinated metabolites of thyroid hormones (THs). Of all possible thyronamine variants, only 3-iodothyronamine (3-T 1 AM) and iodine-free thyronamine (T 0 AM) have been detected in vivo. While intensive research has been done on the (patho-)physiological action of 3-T 1 AM, the role of T 0 AM has been studied less intensively.