Open AccessSalvianolic Acid B Ameliorates Cognitive Deficits Through IGF-1/Akt Pathway in Rats with Vascular Dementia
Author(s) -
Xiaowei Ma,
Weiwei Xu,
Zhongxia Zhang,
Na Liu,
Jie Yang,
Mingwei Wang,
Yanyong Wang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000481849
Subject(s) - vascular dementia , dementia , protein kinase b , medicine , cognition , cognitive decline , signal transduction , endocrinology , neuroscience , psychology , biology , microbiology and biotechnology , disease
BackgroundAims: Salvianolic acid B (SalB) is a natural polyphenolic compound enriched in Salvia miltiorrhiza Bunge. Our study was designed to explore the role of Sal B on cognitive impairment in vascular dementia (VD) model rats, as well as its possible molecular mechanisms.