Open AccessProtective Effects of Microrna-22 Against Endothelial Cell Injury by Targeting NLRP3 Through Suppression of the Inflammasome Signaling Pathway in a Rat Model of Coronary Heart Disease
Author(s) -
Weiqiang Huang,
Peng Wei,
Ri-Qi Lin,
Feng Huang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000481846
Subject(s) - apoptosis , inflammasome , microrna , caspase 1 , blot , microbiology and biotechnology , endothelial stem cell , cell , western blot , signal transduction , medicine , chemistry , cancer research , biology , inflammation , immunology , in vitro , biochemistry , gene
This study aimed to identify the role of microRNA-22 (miR-22) in endothelial cell (EC) injury in coronary heart disease (CHD) by targeting NLRP3 through the inflammasome signaling pathway.