Open AccessIodine Promotes Tumorigenesis of Thyroid Cancer by Suppressing Mir-422a and Up-Regulating MAPK1
Author(s) -
Junyi Wang,
Hao Yang,
Yiran Si,
Dongzhi Hu,
Yang Yu,
Yan Zhang,
Ming Gao,
Haiyang Zhang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000481844
Subject(s) - carcinogenesis , microrna , thyroid cancer , cancer research , thyroid carcinoma , thyroid , cell growth , cancer , medicine , biology , biochemistry , gene
Iodine may trigger tumorigenesis and development of thyroid carcinoma, but the mechanisms involved remained elusive. MicroRNA (MiRNAs) are known to be involved in each stage of cancer development; however, the role of miRNAs in iodine-induced tumorigenesis of thyroid carcinoma remained unknown. In this study, we aimed at investigating miRNA related signaling pathway in thyroid cancer cells.