Open AccessLong-Term Surface Electrode Impedance Recordings Associated with Gliosis for a Closed-Loop Neurostimulation Device
Author(s) -
Karl Sillay,
Solomon Ondoma,
Brett Wingeier,
Dominic T. Schomberg,
Priyanka Sharma,
Rahul Kumar,
Gurwattan S. Miranpuri,
Justin Williams
Publication year - 2018
Publication title -
annals of neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.545
H-Index - 19
eISSN - 0976-3260
pISSN - 0972-7531
DOI - 10.1159/000481805
Subject(s) - gliosis , neurostimulation , medicine , epilepsy , biomedical engineering , neuroscience , pathology , stimulation , psychology , psychiatry
Closed-loop neurostimulation is a novel alternative therapy for medically intractable focal epilepsy for patients who are not candidates for surgical resection of a seizure focus. Electrodes for this system can be implanted either within the brain parenchyma or in the subdural space. The electrodes then serve the dual role of detecting seizures and delivering an electrical signal aimed at aborting seizure activity. The Responsive Neurostimulation (RNS®) system (Neuropace, Mountain View, CA, USA) is an FDA-approved implantable device designed for this purpose.