Open AccessStimulation of Anxiety-Like Behavior via ERK Pathway by Competitive Serotonin Receptors 2A and 1A in Post-Traumatic Stress Disordered Mice
Author(s) -
Mingjun Xiang,
Yuting Jiang,
Zhiying Hu,
Yang Yang,
Benson O. A. Botchway,
Marong Fang
Publication year - 2017
Publication title -
neurosignals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.755
H-Index - 67
eISSN - 1424-8638
pISSN - 1424-862X
DOI - 10.1159/000481791
Subject(s) - anxiety , open field , 5 ht receptor , stimulation , psychology , serotonin , receptor , elevated plus maze , mapk/erk pathway , neuroscience , 5 ht2a receptor , medicine , endocrinology , signal transduction , biology , microbiology and biotechnology , psychiatry
Serotonin 5HT2A and 5HT1A receptors (5HT2AR, 5HT1AR) have the closest connection to anxiety-like behavior in post-traumatic stress disorder (PTSD). However, the underlying mechanism remains unclear. In this study, we explored the connection between 5HT2A and 5HT1A receptors and anxiety-like behavior.