Open AccessXRCC2-Deficient Cells are Highly Sensitive to 5-Fluorouracil in Colorectal Cancer
Author(s) -
Yong-zhou Zhang,
Jing An,
Yuxin Liu,
Xianchuang Wu,
Shanshan Han,
Xuequn Ren,
Changjiang Qin
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000481762
Subject(s) - colorectal cancer , cancer research , cell cycle , gene knockdown , dna repair , flow cytometry , medicine , cancer , apoptosis , oncology , biology , dna , immunology , genetics , biochemistry
Inhibition of the repair of 5-fluorouracil (5-FU)-induced DNA lesions may improve the responses of tumors to anticancer agents. XRCC2 is a key factor in DNA repair. However, the role of XRCC2 in the chemoresistance of colorectal cancer (CRC) treated with 5-FU remains unclear. The aim of this study is to investigate whether XRCC2 expression affects the chemosensitivity of colorectal cancer.