XRCC2-Deficient Cells are Highly Sensitive to 5-Fluorouracil in Colorectal Cancer | Zendy

Yong-zhou Zhang | Zendy; Jihong An | Zendy; Yuxin Liu | Zendy; Xianchuang Wu | Zendy; Shanshan Han | Zendy; Xuequn Ren | Zendy; Changjiang Qin | Zendy

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XRCC2-Deficient Cells are Highly Sensitive to 5-Fluorouracil in Colorectal Cancer

Author(s) -

Yong-zhou Zhang,

Jihong An,

Yuxin Liu,

Xianchuang Wu,

Shanshan Han,

Xuequn Ren,

Changjiang Qin

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000481762

Subject(s) - colorectal cancer , cancer research , cell cycle , gene knockdown , dna repair , flow cytometry , medicine , cancer , apoptosis , oncology , biology , dna , immunology , genetics , biochemistry

Inhibition of the repair of 5-fluorouracil (5-FU)-induced DNA lesions may improve the responses of tumors to anticancer agents. XRCC2 is a key factor in DNA repair. However, the role of XRCC2 in the chemoresistance of colorectal cancer (CRC) treated with 5-FU remains unclear. The aim of this study is to investigate whether XRCC2 expression affects the chemosensitivity of colorectal cancer.

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