Open AccessMiR-26a Mediates Ultraviolet B-Induced Apoptosis by Targeting Histone Methyltransferase EZH2 Depending on Myc Expression
Author(s) -
Ting Zhang,
Hua Qian,
Chenyao Hu,
Hui Lu,
Ji-Bing Li,
Ya-Fen Wu,
Wei Li
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000481759
Subject(s) - hacat , ezh2 , apoptosis , carcinogenesis , cancer research , downregulation and upregulation , histone methyltransferase , uvb induced apoptosis , biology , methyltransferase , microbiology and biotechnology , histone , chemistry , cell culture , cancer , programmed cell death , methylation , gene , genetics , caspase
Ultraviolet B (UVB) damage is the most essential etiological factor in skin carcinogenesis, and apoptosis leads to the efficient elimination of UVB-damaged cells. However, the mechanisms underlying resistance to UVB-induced apoptosis remain unclear.