Open AccessIntensified Beclin-1 Mediated by Low Expression of Mir-30a-5p Promotes Chemoresistance in Human Small Cell Lung Cancer
Author(s) -
Yang Xiang,
Fan Bai,
Yang Xu,
Yitian Chen,
Longbang Chen
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000481754
Subject(s) - cisplatin , autophagy , etoposide , apoptosis , cancer research , transfection , cell cycle , cell growth , cell culture , downregulation and upregulation , biology , metastasis , cancer cell , flow cytometry , chemotherapy , cancer , medicine , immunology , biochemistry , genetics , gene
Although small cell lung cancer (SCLC) is sensitive to initial chemotherapy, patients experience tumor recurrence and metastasis, leading to treatment failure. Autophagy as a protective pattern for cell survival in the harsh environment plays an important role in chemoresistance. However, the role of Beclin-1, a key regulator of autophagy in the drug-resistance of SCLC cells is still poorly understood. In the current study, we focused on the effect and regulation of Beclin-1 in chemoresistance of SCLC cells.