Intensified Beclin-1 Mediated by Low Expression of Mir-30a-5p Promotes Chemoresistance in Human Small Cell Lung Cancer | Zendy

Xiang Yang | Zendy; Fan Bai | Zendy; Yichen Xu | Zendy; Yitian Chen | Zendy; Longbang Chen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Intensified Beclin-1 Mediated by Low Expression of Mir-30a-5p Promotes Chemoresistance in Human Small Cell Lung Cancer

Author(s) -

Xiang Yang,

Fan Bai,

Yichen Xu,

Yitian Chen,

Longbang Chen

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000481754

Subject(s) - cisplatin , autophagy , etoposide , apoptosis , cancer research , transfection , cell cycle , cell growth , cell culture , downregulation and upregulation , biology , metastasis , cancer cell , flow cytometry , chemotherapy , cancer , medicine , immunology , biochemistry , genetics , gene

Although small cell lung cancer (SCLC) is sensitive to initial chemotherapy, patients experience tumor recurrence and metastasis, leading to treatment failure. Autophagy as a protective pattern for cell survival in the harsh environment plays an important role in chemoresistance. However, the role of Beclin-1, a key regulator of autophagy in the drug-resistance of SCLC cells is still poorly understood. In the current study, we focused on the effect and regulation of Beclin-1 in chemoresistance of SCLC cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research