Open AccessModulation of the Proteasome Pathway by Nano-Curcumin and Curcumin in Retinal Pigment Epithelial Cells
Author(s) -
J. Emanuel Ramos de Carvalho,
Milan T. Verwoert,
I. M. C. Vogels,
Sabine Schipper-Krom,
C. J. F. Van Noorden,
Eric Reits,
Ingeborg Klaassen,
Reinier O. Schlingemann
Publication year - 2017
Publication title -
ophthalmic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 54
eISSN - 1423-0259
pISSN - 0030-3747
DOI - 10.1159/000481261
Subject(s) - curcumin , proteasome , oxidative stress , proteasome inhibitor , chemistry , reactive oxygen species , biochemistry , microbiology and biotechnology , biology , pharmacology
Curcumin has multiple biological effects including the modulation of protein homeostasis by the ubiquitin-proteasome system. The purpose of this study was to assess the in vitro cytotoxic and oxidative effects of nano-curcumin and standard curcumin and characterize their effects on proteasome regulation in retinal pigment epithelial (RPE) cells.