Open AccessHighly Selective Endothelin-1 Receptor A Inhibition Prevents Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice
Author(s) -
Nikolaos Manitsopoulos,
Ioanikitopoulou,
Nikolaos A. Maniatis,
Christina Μagkou,
Αναστασία Κοτανίδου,
Stylianos E. Orfanos
Publication year - 2017
Publication title -
respiration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.264
H-Index - 81
eISSN - 1423-0356
pISSN - 0025-7931
DOI - 10.1159/000481201
Subject(s) - medicine , bleomycin , bronchoalveolar lavage , lung , pulmonary fibrosis , fibrosis , inflammation , hypoxic pulmonary vasoconstriction , endothelin receptor , pulmonary compliance , interstitial lung disease , endothelin 1 , idiopathic pulmonary fibrosis , immunology , pharmacology , pathology , receptor , chemotherapy
Pulmonary fibrosis is a chronic disease, which progressively leads to respiratory failure and ultimately death. Endothelin-1 (ET-1), a vasoconstrictor secreted by endothelial cells, promotes vasoconstriction by activation of its receptors A and B.