Highly Selective Endothelin-1 Receptor A Inhibition Prevents Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice | Zendy

Nikolaos Manitsopoulos | Zendy; Ioanikitopoulou | Zendy; Nikolaos A. Maniatis | Zendy; Christina Μagkou | Zendy; Αναστασία Κοτανίδου | Zendy; Stylianos E. Orfanos | Zendy

Open Access

Highly Selective Endothelin-1 Receptor A Inhibition Prevents Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice

Author(s) -

Nikolaos Manitsopoulos,

Ioanikitopoulou,

Nikolaos A. Maniatis,

Christina Μagkou,

Αναστασία Κοτανίδου,

Stylianos E. Orfanos

Publication year - 2017

Publication title -

respiration

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.264

H-Index - 81

eISSN - 1423-0356

pISSN - 0025-7931

DOI - 10.1159/000481201

Subject(s) - medicine , bleomycin , bronchoalveolar lavage , lung , pulmonary fibrosis , fibrosis , inflammation , hypoxic pulmonary vasoconstriction , endothelin receptor , pulmonary compliance , interstitial lung disease , endothelin 1 , idiopathic pulmonary fibrosis , immunology , pharmacology , pathology , receptor , chemotherapy

Pulmonary fibrosis is a chronic disease, which progressively leads to respiratory failure and ultimately death. Endothelin-1 (ET-1), a vasoconstrictor secreted by endothelial cells, promotes vasoconstriction by activation of its receptors A and B.

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