Open AccessLow- versus High-Dose and Early versus Late Parenteral Amino-Acid Administration in Very-Low-Birth-Weight Infants: A Systematic Review and Meta-Analysis
Author(s) -
Erika K.S.M. Leenders,
Marita de Waard,
Johannes B. van Goudoever
Publication year - 2017
Publication title -
neonatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.399
H-Index - 84
eISSN - 1661-7819
pISSN - 1661-7800
DOI - 10.1159/000481192
Subject(s) - medicine , parenteral nutrition , meta analysis , randomized controlled trial , low birth weight , birth weight , pediatrics , amino acid , cochrane library , nitrogen balance , gestational age , pregnancy , biology , biochemistry , chemistry , genetics , organic chemistry , nitrogen
Providing parenteral amino acids to very-low-birth-weight infants during the first weeks of life is critical for adequate growth and neurodevelopment. However, there is no consensus about what dose is appropriate or when to initiate supplementation. As a result, daily practice varies among neonatal intensive care units. The objective of our study was to determine the effects of early parenteral amino-acid supplementation (within 24 h of birth) versus later initiation and high dose (>3.0 g/kg/day) versus a lower dose on growth and morbidities.