Open AccessDown-Regulation of Lncrna MALAT1 Attenuates Neuronal Cell Death Through Suppressing Beclin1-Dependent Autophagy by Regulating Mir-30a in Cerebral Ischemic Stroke
Author(s) -
Dong Guo,
Ji Ma,
Lei Yan,
Tengfei Li,
Zhiguo Li,
Xinwei Han,
Shaofeng Shui
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000480337
Subject(s) - autophagy , malat1 , ischemia , in vivo , programmed cell death , microbiology and biotechnology , brain ischemia , cancer research , medicine , biology , pharmacology , apoptosis , downregulation and upregulation , biochemistry , long non coding rna , gene
LncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was reported to be highly expressed in an in vitro mimic of ischemic stroke conditions. However, the exact biological role of MALAT1 and its underlying mechanism in ischemic stroke remain to be elucidated.