Open AccessPost-Translational Modification of Adiponectin Affects Lipid Accumulation, Proliferation and Migration of Vascular Smooth Muscle Cells
Author(s) -
Xinzhong Chen,
Yanhong Yuan,
Qin Wang,
Fei Xie,
Dongsheng Xia,
Xianguo Wang,
Yongzhong Wei,
Ting Xie
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000480336
Subject(s) - glycosylation , adipokine , vascular smooth muscle , adiponectin , medicine , endocrinology , chemistry , biochemistry , biology , smooth muscle , leptin , obesity , insulin resistance
Adiponectin (Apn) is a multifunctional adipokine that circulates as several oligomeric complexes in the blood stream. Previous reports showed that several conserved lysine residues within the N-terminal collagenous domain of Apn are modified by hydroxylation and glycosylation. Here, we investigated the potential roles of post-translational modifications of Apn on the function of human vascular smooth muscle cells (VSMCs).