Open AccessExosomes Derived from Mesenchymal Stem Cells Rescue Myocardial Ischaemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy Via AMPK and Akt Pathways
Author(s) -
Liang Liu,
Xian Jin,
CuiFen Hu,
Rong Li,
Zhong’e Zhou,
Chengxing Shen
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000480317
Subject(s) - autophagy , pi3k/akt/mtor pathway , exosome , protein kinase b , apoptosis , microbiology and biotechnology , mesenchymal stem cell , annexin , cardioprotection , viability assay , microvesicles , ampk , chemistry , biology , medicine , ischemia , microrna , protein kinase a , biochemistry , kinase , gene
Reperfusion after an ischaemic insult might cause infarct extension. Mesenchymal stem cell (MSC)-derived exosomes could attenuate myocardial remodelling in animal models of myocardial ischaemia reperfusion injury (MIRI), and the present study aimed to explore the related mechanisms.