Exosomes Derived from Mesenchymal Stem Cells Rescue Myocardial Ischaemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy Via AMPK and Akt Pathways | Zendy

Liang Liu | Zendy; Xian Jin | Zendy; CuiFen Hu | Zendy; Rong Li | Zendy; Zhong’e Zhou | Zendy; Chengxing Shen | Zendy

Open Access

Exosomes Derived from Mesenchymal Stem Cells Rescue Myocardial Ischaemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy Via AMPK and Akt Pathways

Author(s) -

Liang Liu,

Xian Jin,

CuiFen Hu,

Rong Li,

Zhong’e Zhou,

Chengxing Shen

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000480317

Subject(s) - autophagy , pi3k/akt/mtor pathway , exosome , protein kinase b , apoptosis , microbiology and biotechnology , mesenchymal stem cell , annexin , cardioprotection , viability assay , microvesicles , ampk , chemistry , biology , medicine , ischemia , microrna , protein kinase a , biochemistry , kinase , gene

Reperfusion after an ischaemic insult might cause infarct extension. Mesenchymal stem cell (MSC)-derived exosomes could attenuate myocardial remodelling in animal models of myocardial ischaemia reperfusion injury (MIRI), and the present study aimed to explore the related mechanisms.

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