Open AccessLong Non-Coding RNA MEG3 Downregulation Triggers Human Pulmonary Artery Smooth Muscle Cell Proliferation and Migration via the p53 Signaling Pathway
Author(s) -
Zengxian Sun,
Xiaowei Nie,
Shuyang Sun,
Shilin Dong,
Chunluan Yuan,
Yanli Li,
Bing-Xin Xiao,
Jie Dong,
Yun Liu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000480218
Subject(s) - gene knockdown , meg3 , long non coding rna , vascular smooth muscle , cell cycle , biology , cancer research , cell growth , downregulation and upregulation , cyclin d1 , microbiology and biotechnology , cell , pathology , endocrinology , medicine , cell culture , gene , biochemistry , smooth muscle , genetics
Increasing evidence has demonstrated a significant role of long non-coding RNAs (lncRNAs) in diverse biological processes, and many of which are likely to have functional roles in vascular remodeling. However, their functions in pulmonary arterial hypertension (PAH) remain largely unknown. Pulmonary vascular remodeling is an important pathological feature of PAH, leading to increased vascular resistance and reduced compliance. Pulmonary artery smooth muscle cells (PASMCs) dysfunction is involved in vascular remodeling. Long noncoding RNAs are potential regulators of PASMCs function. Herein, we determined whether long noncoding RNA-maternally expressed gene 3 (MEG3) was involved in PAH-related vascular remodeling.