Open AccessMicroRNA-199a-5p Induced Autophagy and Inhibits the Pathogenesis of Ankylosing Spondylitis by Modulating the mTOR Signaling via Directly Targeting Ras Homolog Enriched in Brain (Rheb)
Author(s) -
Yahan Wang,
JianPing Luo,
Xiaogang Wang,
Bin Yang,
Liyang Cui
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000480211
Subject(s) - rheb , autophagy , pi3k/akt/mtor pathway , microrna , cancer research , pathogenesis , mechanistic target of rapamycin , atg5 , transfection , downregulation and upregulation , biology , mtorc1 , chemistry , signal transduction , microbiology and biotechnology , immunology , cell culture , apoptosis , gene , biochemistry , genetics
Ankylosing spondylitis (AS) is an inflammatory and immune disease leading to disability. Autophagy has been identified as a potential player in understanding the pathogenesis of AS.