Open AccessAdiponectin Inhibits TNF-α-Activated PAI-1 Expression Via the cAMP-PKA-AMPK-NF-κB Axis in Human Umbilical Vein Endothelial Cells
Author(s) -
Yijian Chen,
Yongliang Zheng,
Liping Liu,
Cheng Chang Lin,
Can Liao,
Liuyan Xin,
Shengyi Zhong,
Qilai Cheng,
Liqun Zhang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000480006
Subject(s) - umbilical vein , downregulation and upregulation , tumor necrosis factor alpha , ampk , forskolin , plasminogen activator inhibitor 1 , activator (genetics) , chemistry , endocrinology , plasminogen activator , adiponectin , medicine , fibrinolysis , nf κb , signal transduction , biology , protein kinase a , receptor , biochemistry , kinase , insulin resistance , insulin , in vitro , gene
Tumor necrosis factor (TNF)-α can upregulate the expression of plasminogen activator inhibitor (PAI)-1, an inhibitor of fibrinolysis. Adiponectin (Adp) antagonizes TNF-α by negatively regulating its expression in various tissues. In the present study, the ability of Adp to suppress TNF-α-induced PAI-1 upregulation and the underlying mechanisms were evaluated.