Open AccessKrüppel-Like Factor 2 Regulates Degradation of Type II Collagen by Suppressing the Expression of Matrix Metalloproteinase (MMP)-13
Author(s) -
Yuan Yuan,
Honglue Tan,
Peng-yi Dai
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000479991
Subject(s) - klf2 , gene knockdown , western blot , matrix metalloproteinase , chemistry , microbiology and biotechnology , cancer research , biology , downregulation and upregulation , biochemistry , apoptosis , gene
Krüppel-like factor 2 (KLF2) plays an essential role in the inhibition of endothelial cell and macrophage activation during the inflammatory process. However, the roles of KLF2 in chondrocytes and the pathological progression of osteoarthritis (OA) remain unknown. The aim of this study was to investigate the function of KLF2 in the inhibition of cartilage matrix destruction in chondrocytes.