Open AccessAcid-Base and Electrolyte Disorders in Patients with and without Chronic Kidney Disease: An Update
Author(s) -
Tsering Dhondup,
Qi Qian
Publication year - 2017
Publication title -
kidney diseases
Language(s) - English
Resource type - Journals
eISSN - 2296-9381
pISSN - 2296-9357
DOI - 10.1159/000479968
Subject(s) - metabolic acidosis , alkalosis , electrolyte disorder , kidney disease , metabolic alkalosis , medicine , acidosis , homeostasis , acid–base imbalance , disease , kidney , intensive care medicine , hyponatremia
Kidneys play a pivotal role in the maintenance and regulation of acid-base and electrolyte homeostasis, which is the prerequisite for numerous metabolic processes and organ functions in the human body. Chronic kidney diseases compromise the regulatory functions, resulting in alterations in electrolyte and acid-base balance that can be life-threatening. In this review, we discuss the renal regulations of electrolyte and acid-base balance and several common disorders including metabolic acidosis, alkalosis, dysnatremia, dyskalemia, and dysmagnesemia. Common disorders in chronic kidney disease are also discussed. The most recent and relevant advances on pathophysiology, clinical characteristics, diagnosis, and management of these conditions have been incorporated.