Open AccessInsulin Influences LPS-Induced TNF-α and IL-6 Release Through Distinct Pathways in Mouse Macrophages from Different Compartments
Author(s) -
Fernando Henrique Galvão Tessaro,
Thaís Soprani Ayala,
Eduardo Lima Nolasco,
Leonardo Mendes Bella,
Joilson O. Martins
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000479904
Subject(s) - medicine , endocrinology , wortmannin , insulin , protein kinase b , mapk/erk pathway , pi3k/akt/mtor pathway , ly294002 , tumor necrosis factor alpha , p38 mitogen activated protein kinases , cytokine , inflammation , kinase , chemistry , biology , signal transduction , microbiology and biotechnology
Diabetic subjects are more susceptible to infections, which is partially due to insulin deficiency and hyperglycemia. We hypothesized that insulin influences cytokine release by macrophages from diabetic C57BL/6 mice stimulated with lipopolysaccharides (LPS).