Open AccessMiR-143-5p Deficiency Triggers EMT and Metastasis by Targeting HIF-1α in Gallbladder Cancer
Author(s) -
Min He,
Ming Zhan,
Wei Chen,
Sunwang Xu,
Manmei Long,
Hui Shen,
Yan-Hui Shi,
Qiang Liu,
Man Mohan,
Jian Wang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000479903
Subject(s) - gallbladder cancer , cancer research , epithelial–mesenchymal transition , metastasis , western blot , microrna , cancer , immunohistochemistry , biology , biomarker , pathology , medicine , biochemistry , gene
Early metastasis plays a pivotal role in tumor-caused death in gallbladder cancer (GBC) patients. Increasing evidence suggest that miR-143-5p is an active player involved in cancer metastasis and a potential therapeutic target. However, its role in the development of GBC cells remains unclear. The aim of this study is to reveal the inhibiting effects of miR-143-5p on the proliferation and metastasis in GBC.