MiR-143-5p Deficiency Triggers EMT and Metastasis by Targeting HIF-1α in Gallbladder Cancer | Zendy

Min He | Zendy; Ming Zhan | Zendy; Wei Chen | Zendy; Sunwang Xu | Zendy; Manmei Long | Zendy; Hui Shen | Zendy; Yongheng Shi | Zendy; Qiang Liu | Zendy; Man Mohan | Zendy; Jian Wang | Zendy

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MiR-143-5p Deficiency Triggers EMT and Metastasis by Targeting HIF-1α in Gallbladder Cancer

Author(s) -

Min He,

Ming Zhan,

Wei Chen,

Sunwang Xu,

Manmei Long,

Hui Shen,

Yongheng Shi,

Qiang Liu,

Man Mohan,

Jian Wang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000479903

Subject(s) - gallbladder cancer , cancer research , epithelial–mesenchymal transition , metastasis , western blot , microrna , cancer , immunohistochemistry , biology , biomarker , pathology , medicine , biochemistry , gene

Early metastasis plays a pivotal role in tumor-caused death in gallbladder cancer (GBC) patients. Increasing evidence suggest that miR-143-5p is an active player involved in cancer metastasis and a potential therapeutic target. However, its role in the development of GBC cells remains unclear. The aim of this study is to reveal the inhibiting effects of miR-143-5p on the proliferation and metastasis in GBC.

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