Neonatal Exposure to 6-n-Propyl-Thiouracil, an Anti-Thyroid Drug, Alters Expression of Hepatic DNA Methyltransferases, Methyl CpG-Binding Proteins, Gadd45a, p53, and PCNA in Adult Male Rats | Zendy

Suresh Kumar Bunker | Zendy; Jagneshwar Dandapat | Zendy; G.B.N. Chainy | Zendy; Sunil Kumar Sahoo | Zendy; Prabhat Kumar Nayak | Zendy

Open Access

Neonatal Exposure to 6-n-Propyl-Thiouracil, an Anti-Thyroid Drug, Alters Expression of Hepatic DNA Methyltransferases, Methyl CpG-Binding Proteins, Gadd45a, p53, and PCNA in Adult Male Rats

Author(s) -

Suresh Kumar Bunker,

Jagneshwar Dandapat,

G.B.N. Chainy,

Sunil Kumar Sahoo,

Prabhat Kumar Nayak

Publication year - 2017

Publication title -

european thyroid journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.23

H-Index - 10

eISSN - 2235-0802

pISSN - 2235-0640

DOI - 10.1159/000479681

Subject(s) - proliferating cell nuclear antigen , dna methylation , methyltransferase , endocrinology , medicine , dnmt1 , thiouracil , downregulation and upregulation , dna damage , liver function , methylation , thyroid , biology , gene expression , dna , immunohistochemistry , biochemistry , gene

Neonatal 6-n-propyl-2-thiouracil (PTU) exposure to male rats is reported to impair liver function in adulthood. However, the mechanism by which the drug impairs liver function is not well known.

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