Open AccessNeonatal Exposure to 6-n-Propyl-Thiouracil, an Anti-Thyroid Drug, Alters Expression of Hepatic DNA Methyltransferases, Methyl CpG-Binding Proteins, Gadd45a, p53, and PCNA in Adult Male Rats
Author(s) -
Suresh Kumar Bunker,
Jagneshwar Dandapat,
G.B.N. Chainy,
Sunil Kumar Sahoo,
Prabhat Kumar Nayak
Publication year - 2017
Publication title -
european thyroid journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.23
H-Index - 10
eISSN - 2235-0802
pISSN - 2235-0640
DOI - 10.1159/000479681
Subject(s) - proliferating cell nuclear antigen , methyltransferase , medicine , endocrinology , dna methylation , thiouracil , dnmt1 , downregulation and upregulation , liver function , dna damage , methylation , thyroid , biology , gene expression , dna , immunohistochemistry , biochemistry , gene
Neonatal 6-n-propyl-2-thiouracil (PTU) exposure to male rats is reported to impair liver function in adulthood. However, the mechanism by which the drug impairs liver function is not well known.