Open AccessAlpha-Lipoic Acid Alleviates High-Glucose Suppressed Osteogenic Differentiation of MC3T3-E1 Cells via Antioxidant Effect and PI3K/Akt Signaling Pathway
Author(s) -
Kai Dong,
Pin Hao,
Sheng Xu,
Shutai Liu,
Wenjuan Zhou,
Xilong Yue,
Xiaohui RauschFan,
Zhonghao Liu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000479605
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , oxidative stress , chemistry , alkaline phosphatase , reactive oxygen species , superoxide dismutase , medicine , antioxidant , endocrinology , signal transduction , biochemistry , biology , enzyme
Patients with diabetes mellitus have a higher risk of dental implant failure. One major cause is high-glucose induced oxidative stress. Alpha-lipoic acid (ALA), a naturally occurring compound and dietary supplement, has been established as a potent antioxidant that is a strong scavenger of free radicals. However, few studies have yet investigated the effect of ALA on osteogenic differentiation of osteoblasts cultured with high glucose medium. The aim of this study is to investigate the effects of ALA on the osteoblastic differentiation in MC3T3-E1 cells under high glucose condition.