Open AccessSilencing of Prrx2 Inhibits the Invasion and Metastasis of Breast Cancer both In Vitro and In Vivo by Reversing Epithelial-Mesenchymal Transition
Author(s) -
ZhiDong Lv,
Haibo Wang,
Xiangping Liu,
Lina Jin,
Ruowu Shen,
Xingang Wang,
Bin Kong,
Huili Qu,
Funian Li,
Qifeng Yang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000479542
Subject(s) - epithelial–mesenchymal transition , cancer research , wnt signaling pathway , gene knockdown , metastasis , gene silencing , breast cancer , biology , cancer , small hairpin rna , medicine , signal transduction , apoptosis , microbiology and biotechnology , biochemistry , gene
Epithelial-mesenchymal transition (EMT) is recognized as a crucial mechanism in breast cancer progression and metastasis. Paired-related homeobox 2 (Prrx2) has been identified as a new EMT inducer in cancer, but the underlying mechanisms are still poorly understood.