Open AccessZinc Depletion by TPEN Induces Apoptosis in Human Acute Promyelocytic NB4 Cells
Author(s) -
Bo Zhu,
Jiayu Wang,
Feng Zhou,
Yingting Liu,
Yueyang Lai,
Jie Wang,
Xiao Chen,
Dianhua Chen,
Lan Luo,
Hua Zhang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000479539
Subject(s) - apoptosis , nitric oxide , intracellular , flow cytometry , microbiology and biotechnology , acute promyelocytic leukemia , zinc , chemistry , signal transduction , reactive oxygen species , biology , biochemistry , endocrinology , retinoic acid , organic chemistry , gene
The effects of zinc signaling on proliferation or apoptosis of leukemia cells remain elusive. In the present study, we used N, N, N', N'-tetrakis-(2-pyridylmethyl)-ethylene-diamine (TPEN), a membrane-permeable zinc chelator, to evaluate the effect of zinc depletion on survival and apoptosis of NB4 acute promyelocytic leukemia (APL) cells.