Open AccessEffect of Adjuvant Chemotherapy on Elderly Colorectal Cancer Patients: Lack of Evidence
Author(s) -
Ulrich Nitsche,
Christian Stöß,
Helmut Friess
Publication year - 2017
Publication title -
gastrointestinal tumors
Language(s) - English
Resource type - Journals
eISSN - 2296-3766
pISSN - 2296-3774
DOI - 10.1159/000479318
Subject(s) - medicine , colorectal cancer , adjuvant , chemotherapy , oncology , stage (stratigraphy) , randomized controlled trial , cancer , clinical trial , adjuvant chemotherapy , incidence (geometry) , inclusion and exclusion criteria , gastroenterology , pathology , alternative medicine , paleontology , physics , breast cancer , optics , biology
Adjuvant chemotherapy has become the standard form of treatment for all patients with stage III colorectal cancer and is also recommended for patients with stage II disease and defined risk factors. However, clinical studies that evaluate the effect of adjuvant treatment regimens have a selection bias in favor of younger patients, so that even retrospective subgroup analyses cannot define the best therapeutic procedure in elderly patients with comorbidities.