Open AccessInfusion of Valproic Acid Into the Renal Medulla Activates Stem Cell Population and Attenuates Salt-Sensitive Hypertension in Dahl S Rats
Author(s) -
Zhengchao Wang,
Qing Zhu,
Weili Wang,
Fan Yi,
PinLan Li,
Krishna M. Boini,
Ningjun Li
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000478955
Subject(s) - valproic acid , renal medulla , endocrinology , stem cell , population , medicine , pharmacology , kidney , chemistry , microbiology and biotechnology , biology , neuroscience , environmental health , epilepsy
Our previous study has detected a stem cell deficiency in the renal medulla in Dahl salt-sensitive (S) rats. This study determined whether infusion of valproic acid (VA), an agent known to stimulate the stem cell function, attenuated salt-sensitive hypertension in Dahl S rats.