Integrated High Throughput Analysis Identifies GSK3 as a Crucial Determinant of p53-Mediated Apoptosis in Lung Cancer Cells | Zendy

Yu Zhang | Zendy; Chenyang Zhu | Zendy; Bangyao Sun | Zendy; Jiawei Lv | Zendy; Liu Z | Zendy; Shengwang Liu | Zendy; Hai Li | Zendy

Open Access

Integrated High Throughput Analysis Identifies GSK3 as a Crucial Determinant of p53-Mediated Apoptosis in Lung Cancer Cells

Author(s) -

Yu Zhang,

Chenyang Zhu,

Bangyao Sun,

Jiawei Lv,

Liu Z,

Shengwang Liu,

Hai Li

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000478873

Subject(s) - a549 cell , small hairpin rna , biology , cancer research , lung cancer , apoptosis , cell cycle , cell cycle checkpoint , microbiology and biotechnology , gene , genetics , gene knockdown , medicine , oncology

p53 dysfunction is frequently observed in lung cancer. Although restoring the tumour suppressor function of p53 is recently approved as a putative strategy for combating cancers, the lack of understanding of the molecular mechanism underlying p53-mediated lung cancer suppression has limited the application of p53-based therapies in lung cancer.

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