Open AccessIntegrated High Throughput Analysis Identifies GSK3 as a Crucial Determinant of p53-Mediated Apoptosis in Lung Cancer Cells
Author(s) -
Yu Zhang,
Chen Zhu,
Bo Sun,
Jiawei Lv,
Liu Z,
Shengwang Liu,
Hai Li
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000478873
Subject(s) - a549 cell , small hairpin rna , biology , cancer research , lung cancer , apoptosis , cell cycle , cell cycle checkpoint , microbiology and biotechnology , gene , genetics , gene knockdown , medicine , oncology
p53 dysfunction is frequently observed in lung cancer. Although restoring the tumour suppressor function of p53 is recently approved as a putative strategy for combating cancers, the lack of understanding of the molecular mechanism underlying p53-mediated lung cancer suppression has limited the application of p53-based therapies in lung cancer.