Polymyxin B Attenuates LPS-Induced Death but Aggravates Radiation-Induced Death via TLR4-Myd88-IL-6 Pathway | Zendy

Ying Cheng | Zendy; Jicong Du | Zendy; Jiaqi Han | Zendy; Weimin Sun | Zendy; Fu Gao | Zendy; Pei Zhang | Zendy; Hainan Zhao | Zendy; Ming Chen | Zendy; Jianing Wang | Zendy; Mingyu Wang | Zendy; Suhe Dong | Zendy; Ding Sun | Zendy; Yandong Zhang | Zendy; Jianguo Cui | Zendy; Jianming Cai | Zendy; Cong Liu | Zendy

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Polymyxin B Attenuates LPS-Induced Death but Aggravates Radiation-Induced Death via TLR4-Myd88-IL-6 Pathway

Author(s) -

Ying Cheng,

Jicong Du,

Jiaqi Han,

Weimin Sun,

Fu Gao,

Pei Zhang,

Hainan Zhao,

Ming Chen,

Jianing Wang,

Mingyu Wang,

Suhe Dong,

Ding Sun,

Yandong Zhang,

Jianguo Cui,

Jianming Cai,

Cong Liu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000478767

Subject(s) - polymyxin b , tlr4 , lipopolysaccharide , in vivo , pharmacology , chemistry , tumor necrosis factor alpha , inflammation , immunology , medicine , biology , microbiology and biotechnology , antibiotics

Polymyxin B (PMB) is a cyclic cationic polypeptide antibiotic widely used to counteract the effects of endotoxin contamination, both in vitro and in vivo. Lipopolysaccharide (LPS) is an endotoxin that acts as a radiation protection factor. In this study, we focus on the role of PMB in LPS-induced and radiation-induced mortality in mice.

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