Open AccessPolymyxin B Attenuates LPS-Induced Death but Aggravates Radiation-Induced Death via TLR4-Myd88-IL-6 Pathway
Author(s) -
Ying Cheng,
Jicong Du,
Jiaqi Han,
Weimin Sun,
Fu Gao,
Pei Zhang,
Hainan Zhao,
Ming Chen,
Jianbo Wang,
Mingyu Wang,
Suhe Dong,
Ding-Ping Sun,
Yandong Zhang,
Jianguo Cui,
Jianming Cai,
Cong Liu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000478767
Subject(s) - polymyxin b , tlr4 , lipopolysaccharide , in vivo , pharmacology , chemistry , tumor necrosis factor alpha , inflammation , immunology , medicine , biology , microbiology and biotechnology , antibiotics
Polymyxin B (PMB) is a cyclic cationic polypeptide antibiotic widely used to counteract the effects of endotoxin contamination, both in vitro and in vivo. Lipopolysaccharide (LPS) is an endotoxin that acts as a radiation protection factor. In this study, we focus on the role of PMB in LPS-induced and radiation-induced mortality in mice.