Open AccessCaveolae Depletion Contributes to Vasorelaxant Effects of Chenodeoxycholic Acid
Author(s) -
Zhongchao Wang,
Qiang Lv,
Huan Liu,
Yue Wu,
YunGang Bai,
Yong Cheng,
Yu-Ting Su,
Yuchen Cai,
Jin-Wen Yu,
Jin Ma,
JunXiang Bao
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000478683
Subject(s) - enos , caveolae , chenodeoxycholic acid , chemistry , phenylephrine , cholic acid , nitric oxide , endocrinology , medicine , endothelium , biochemistry , cholesterol , nitric oxide synthase , biology , signal transduction , blood pressure
High concentration of bile acids (BAs) induces hydrophobicity-dependent vasorelaxtant effects with hydrophobic BAs showing greater responses than hydrophilic BAs, of which the underlying mechanisms are still unclear. Caveolae are invaginations on membranes of endothelial cells (ECs) entraping endothelial nitric oxide synthase (eNOS) to prevent its activation, which plays a critical role in regulation of vascular function. The purpose of the present study was to investigate the role of caveolae in vasorelaxant effects of BAs.