Open AccessMacrophage Inflammatory Protein-2 in High Mobility Group Box 1 Secretion of Macrophage Cells Exposed to Lipopolysaccharide
Author(s) -
Chao-Chao Qin,
Guohua Lou,
Ying Yang,
Yanning Liu,
Ying Hu,
MingHua Zheng,
Ping Chen,
Jiliang He,
Zhi Chen
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000478646
Subject(s) - hmgb1 , chemokine , lipopolysaccharide , inflammation , macrophage inflammatory protein , tumor necrosis factor alpha , macrophage , microbiology and biotechnology , chemistry , nitric oxide synthase , interleukin , western blot , immunology , cytokine , biology , nitric oxide , in vitro , endocrinology , biochemistry , gene
Macrophage inflammatory protein-2 (MIP-2), a type of leukocyte chemokine, is primarily produced by macrophages, and levels increase significantly in early inflammation. However, the precise biological functions and mechanisms of MIP-2 in the development of inflammation remain unclear. The purposes of the present study were to investigate the role of MIP-2 in inflammation induced by lipopolysaccharide (LPS) in vitro and to determine the possibility of blocking the high mobility group box 1 (HMGB1) signalling pathway via MIP-2 inhibition.