Macrophage Inflammatory Protein-2 in High Mobility Group Box 1 Secretion of Macrophage Cells Exposed to Lipopolysaccharide | Zendy

Chao-Chao Qin | Zendy; Guohua Lou | Zendy; Ying Yang | Zendy; Yanning Liu | Zendy; Ying Hu | Zendy; Min Zheng | Zendy; Ping Chen | Zendy; Jiliang He | Zendy; Zhi Chen | Zendy

Open Access

Macrophage Inflammatory Protein-2 in High Mobility Group Box 1 Secretion of Macrophage Cells Exposed to Lipopolysaccharide

Author(s) -

Chao-Chao Qin,

Guohua Lou,

Ying Yang,

Yanning Liu,

Ying Hu,

Min Zheng,

Ping Chen,

Jiliang He,

Zhi Chen

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000478646

Subject(s) - hmgb1 , chemokine , lipopolysaccharide , inflammation , macrophage inflammatory protein , tumor necrosis factor alpha , macrophage , microbiology and biotechnology , chemistry , nitric oxide synthase , interleukin , western blot , immunology , cytokine , biology , nitric oxide , in vitro , endocrinology , biochemistry , gene

Macrophage inflammatory protein-2 (MIP-2), a type of leukocyte chemokine, is primarily produced by macrophages, and levels increase significantly in early inflammation. However, the precise biological functions and mechanisms of MIP-2 in the development of inflammation remain unclear. The purposes of the present study were to investigate the role of MIP-2 in inflammation induced by lipopolysaccharide (LPS) in vitro and to determine the possibility of blocking the high mobility group box 1 (HMGB1) signalling pathway via MIP-2 inhibition.

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