Open AccessMiR-495 Promotes Senescence of Mesenchymal Stem Cells by Targeting Bmi-1
Author(s) -
Xiujun Li,
Yuxian Song,
Dan Liŭ,
Jiaojiao Zhao,
Jingjing Xu,
Jing Ren,
Yali Hu,
Zhiqun Wang,
Yayi Hou,
Guangfeng Zhao
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000478069
Subject(s) - mesenchymal stem cell , senescence , microbiology and biotechnology , stem cell , cellular senescence , chemistry , biology , cancer research , phenotype , biochemistry , gene
Mesenchymal stem cells (MSCs) play an important role in regulating angiogenesis and immune balance. Abnormal proliferation and function of MSCs were reported at maternal fetal interface in patients with pre-eclampsia (PE). Micro-RNA-495 was known to be upregulated in the MSCs derived from patients with PE. However, it is not clear whether the up-regulated miR-495 is related to the pathogenesis of PE.