Open AccessEndogenous Parathyroid Hormone Promotes Fracture Healing by Increasing Expression of BMPR2 through cAMP/PKA/CREB Pathway in Mice
Author(s) -
Wei Zhou,
Ling Yu,
Fan Jin,
Bowen Wan,
Tao Jiang,
Jian Yin,
Yao Huang,
Qingqing Li,
Guoyong Yin,
Zhaoxing Hu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000477605
Subject(s) - medicine , endocrinology , cyclic adenosine monophosphate , creb , parathyroid hormone , osteoblast , runx2 , chemistry , bone morphogenetic protein 2 , protein kinase a , signal transduction , bone morphogenetic protein , alkaline phosphatase , adenosine , receptor , biology , phosphorylation , transcription factor , calcium , biochemistry , enzyme , gene , in vitro
Endogenous parathyroid hormone (PTH) plays an important role in fracture healing. This study investigated whether endogenous PTH regulates fracture healing by bone morphogenetic protein (BMP) and/or the transforming growth factor-β (TGF-β) signaling pathway.