Open AccessMicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1
Author(s) -
Yang Cao,
Dan Zhao,
Ping Li,
Lanrong Wang,
Bingli Qiao,
Xiaoyan Qin,
Lei Li,
Yan Wang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000477389
Subject(s) - microrna , cancer research , vcam 1 , cell growth , downregulation and upregulation , transfection , biology , cell adhesion , metastasis , lung cancer , cell culture , cell , stat3 , cancer , medicine , microbiology and biotechnology , signal transduction , biochemistry , genetics , gene
The contribution of the inflammatory mediator interleukin-17 (IL-17) in nonsmall cell lung cancer (NSCLC) malignancy has been reported in the literature. MicroRNA-181a-5p (miR-181a-5p) acts as a tumor suppressor which can regulate target gene at the posttranscriptional level. Our study aimed to investigate the interaction between IL-17 and miR-181a-5p in NSCLC.