Open AccessLong Non-Coding RNA KCNQ1OT1 Promotes Cataractogenesis via miR-214 and Activation of the Caspase-1 Pathway
Author(s) -
Xin Jin,
Jin Hao,
Yan Shi,
Yiyuan Guo,
Hong Zhang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000477330
Subject(s) - gene knockdown , microrna , caspase 3 , microbiology and biotechnology , western blot , biology , small interfering rna , pyroptosis , apoptosis , cell culture , cancer research , transfection , programmed cell death , gene , genetics
KCNQ1OT1 regulates the expression of tissue-specific imprinted genes within the Kcnq1 domain. Imprinted genes are positive regulators of apoptosis, one of the forms of cell death related to cataract formation, and thus may provide novel therapeutic targets for cataract treatment. Here, we studied the role of non-coding RNAs(ncRNA) in cataract formation.