Open AccessLet-7a Inhibits T-Cell Proliferation and IFN-γ Secretion by Down-Regulating STAT3 Expression in Patients with Psoriasis
Author(s) -
Xiaoping Hu,
Qian Xie,
Chaofeng Chen,
Wei Zhang,
Bo Yu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000477120
Subject(s) - transfection , microbiology and biotechnology , cell growth , stat3 , messenger rna , psoriasis , western blot , cell , t cell , biology , cell culture , real time polymerase chain reaction , immunology , signal transduction , gene , immune system , biochemistry , genetics
This study aimed to explore the effects of STAT3 targeting by let-7a on T-cell proliferation and IFN-γ secretion in psoriasis.