Open AccessFolic Acid Modulates Matrix Metalloproteinase-2 Expression, Alleviates Neuropathic Pain, and Improves Functional Recovery in Spinal Cord-Injured Rats
Author(s) -
Gurwattan S. Miranpuri,
Sivan Vadakkadath Meethal,
Emmanuel Sampene,
Abhishek Chopra,
Seah Buttar,
Carrie L. Nacht,
Neydis Moreno,
Krishna Patel,
Lisa Liu,
Anupama Singh,
Chandra K. Singh,
Nithya Hariharan,
Bermans J. Iskandar,
Daniel K. Resnick
Publication year - 2017
Publication title -
annals of neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.545
H-Index - 19
eISSN - 0976-3260
pISSN - 0972-7531
DOI - 10.1159/000475896
Subject(s) - medicine , neuropathic pain , spinal cord , anesthesia , spinal cord injury , context (archaeology) , matrix metalloproteinase , allodynia , hyperalgesia , nociception , biology , paleontology , psychiatry , receptor
The molecular underpinnings of spinal cord injury (SCI) associated with neuropathic pain (NP) are unknown. Recent studies have demonstrated that matrix metalloproteinases (MMPs) such as MMP2 play a critical role in inducing NP following SCI. Promoter methylation of MMPs is known to suppress their transcription and reduce NP. In this context, it has been shown in rodents that folic acid (FA), an FDA approved dietary supplement and key methyl donor in the central nervous system (CNS), increases axonal regeneration and repair of injured CNS in part via methylation.