Open AccessReactive Oxygen Species Generated by CD45- Cells Distinct from Leukocyte Population in Platelet Concentrates Is Correlated with the Expression and Release of Platelet Activation Markers during Storage
Author(s) -
Mehran Ghasemzadeh,
Ehteramolsadat Hosseini,
Amin Shahbaz Ghasabeh,
Kamran Mousavi Hosseini
Publication year - 2018
Publication title -
transfusion medicine and hemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 39
eISSN - 1660-3818
pISSN - 1660-3796
DOI - 10.1159/000475845
Subject(s) - platelet , reactive oxygen species , platelet activation , immunology , population , microbiology and biotechnology , blood bank , chemistry , biology , medicine , emergency medicine , environmental health
Platelet stimulation with agonists is accompanied by the generation of reactive oxygen species (ROS) which promotes further platelet activation and aggregation. Considering different cell populations in platelet concentrates (PCs), this study investigates the correlation of ROS generation with the expression and release of platelet activation markers during storage.