Open AccessVitamin D and Albuminuria in Youth with and without Type 1 Diabetes
Author(s) -
Debika Nandi-Munshi,
Maryam Afkarian,
Kathryn B. Whitlock,
Jamie Crandell,
Ronny A. Bell,
Ralph B. D’Agostino,
Sharon Saydah,
Amy K. Mottl,
Dana Dabelea,
Mary Helen Black,
Elizabeth J. MayerDavis,
Catherine Pihoker
Publication year - 2017
Publication title -
hormone research in paediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.816
H-Index - 89
eISSN - 1663-2826
pISSN - 1663-2818
DOI - 10.1159/000475711
Subject(s) - albuminuria , medicine , type 2 diabetes , endocrinology , national health and nutrition examination survey , vitamin d and neurology , diabetes mellitus , population , environmental health
Background/Aims: In adults, lower vitamin D has been associated with increased albuminuria. This association has not been extensively studied in youth with or without type 1 diabetes. Methods: We examined the cross-sectional association between vitamin D and albuminuria (urine albumin to creatinine ratio ≥30 mg/g) in 8,789 participants of the National Health and Nutrition Survey 2001–2006 (NHANES), who were 6–19 years old. Further, we examined the association between vitamin D and albuminuria in 938 participants from the SEARCH Nutritional Ancillary Study (SNAS), a longitudinal cohort of youth with type 1 diabetes. Results: Of the NHANES participants, 5.3, 19.5, and 53.7% had vitamin D levels <30, 50 and 80 nmol/L, respectively. Albuminuria was present in 12.8% and was more common in younger children, females, non-Hispanic whites, non-obese children, and children with hypertension. After adjustments, there was no association between vitamin D and albuminuria. Among the SNAS participants with type 1 diabetes, we also found no association between baseline vitamin D and subsequent albuminuria in unadjusted or adjusted analyses. Conclusion: We did not find an association between serum vitamin D and albuminuria in either non-diabetic youth or those with type 1 diabetes. Further research is needed to more fully understand this relationship.