Open AccessUp-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis
Author(s) -
Cheng Sun,
Shibin Feng,
Zhengwang Cao,
Jun-Jie Bei,
Qiang Chen,
Weibo Zhao,
Xianjie Xu,
Zhou Zhou,
Zhengping Yu,
Houyuan Hu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000475651
Subject(s) - angiogenesis , matrigel , microbiology and biotechnology , matrix metalloproteinase , vasculogenesis , umbilical vein , chemistry , neovascularization , endothelial stem cell , biology , in vitro , cancer research , biochemistry
Platelet microvesicles (PMVs) contribute to angiogenesis and vasculogenesis, but the mechanisms underlying these contributions have not been fully elucidated. In the present study, we investigated whether PMVs regulate the angiogenic properties of endothelial cells (ECs) via mechanisms extending beyond the transport of angiogenic regulators from platelets.