Open AccessAlpha1-ACT Functions as a Tumour Suppressor in Hepatocellular Carcinoma by Inhibiting the PI3K/AKT/mTOR Signalling Pathway via Activation of PTEN
Author(s) -
Hanzhang Zhu,
Qiaoyu Liu,
Junwei Tang,
Yu Xie,
Xiaoliang Xu,
Yuanguangyan Zhang,
Kangpeng Jin,
Beicheng Sun
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000475648
Subject(s) - pten , pi3k/akt/mtor pathway , cancer research , protein kinase b , apoptosis , cell growth , gene knockdown , biology , chemistry , biochemistry , genetics
To investigate the expression and prognostic value of α1-ACT (Alpha1-antichymotrypsin) in patients with HCC (hepatocellular carcinoma) and identify the mechanism by which α1-ACT inhibits proliferation and promotes apoptosis of HCC.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom