Open AccessAlpha1-ACT Functions as a Tumour Suppressor in Hepatocellular Carcinoma by Inhibiting the PI3K/AKT/mTOR Signalling Pathway via Activation of PTEN
Author(s) -
Hong-Jian Zhu,
Qiaoyu Liu,
Junwei Tang,
Yuan Xie,
Xiaoliang Xu,
Ruyi Huang,
Yuanguangyan Zhang,
Kangpeng Jin,
Beicheng Sun
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000475648
Subject(s) - pten , pi3k/akt/mtor pathway , cancer research , protein kinase b , apoptosis , cell growth , gene knockdown , biology , chemistry , biochemistry , genetics
To investigate the expression and prognostic value of α1-ACT (Alpha1-antichymotrypsin) in patients with HCC (hepatocellular carcinoma) and identify the mechanism by which α1-ACT inhibits proliferation and promotes apoptosis of HCC.