Open AccessEffect of the Serum Inhibited Gene (Si1) on Autophagy and Apoptosis in MCF-7 Breast Cancer Cells
Author(s) -
Li Yu,
Yong Cui,
Wenxue Wang,
Mingxing Ma,
Meizhang Li,
Suiyun Chen
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000475644
Subject(s) - mcf 7 , autophagy , apoptosis , cancer research , breast cancer , cancer , gene , cancer cell , biology , medicine , chemistry , human breast , genetics
The serum inhibited gene (Si1) was named according to its inhibited expression in response to serum exposure. Si1 has an important relationship with tumors. Autophagy and apoptosis are two types of cell death. However, there are few studies regarding the association between Si1 and autophagy, or apoptosis in tumors. In this, we investigated the effect of Si1 on the proliferation and cell cycle progression of MCF-7 cells and its influence on autophagy and apoptosis in MCF-7 cells.