Open AccessAntioxidant and Hepatoprotective Effect of Swertiamarin on Carbon Tetrachloride-Induced Hepatotoxicity via the Nrf2/HO-1 Pathway
Author(s) -
Tao Wu,
Jingjing Li,
Yong Li,
Ho-Young Song
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000475639
Subject(s) - chemistry , ccl4 , carbon tetrachloride , oxidative stress , pharmacology , glutathione peroxidase , liver injury , superoxide dismutase , glutathione , malondialdehyde , antioxidant , alkaline phosphatase , nitric oxide synthase , biochemistry , endocrinology , medicine , enzyme , organic chemistry
Swertiamarin (STM), the main bioactive component in Swertia mussotii Franch (Gentianaceae), has been shown to exert hepatoprotective effects on experimental liver injury. However, the effects and exact mechanisms of STM on carbon tetrachloride (CCl4) causing hepatotoxicity are still unknown. This study investigated the potential protective effects and mechanisms of STM on CCl4-induced liver injury in rats.