Degradation of Mcl-1 through GSK-3β Activation Regulates Apoptosis Induced by Bufalin in Non-Small Cell Lung Cancer H1975 Cells | Zendy

Xiaohong Kang | Zendy; Jing-Hang Zhang | Zendy; Zhang Qing-qin | Zendy; Yanhui Cui | Zendy; Ying Wang | Zendy; Weizheng Kou | Zendy; Zhanhui Miao | Zendy; Ping Lü | Zendy; Lifang Wang | Zendy; XU Zhen-ye | Zendy; Fei Cao | Zendy

Open Access

Degradation of Mcl-1 through GSK-3β Activation Regulates Apoptosis Induced by Bufalin in Non-Small Cell Lung Cancer H1975 Cells

Author(s) -

Xiaohong Kang,

Jing-Hang Zhang,

Zhang Qing-qin,

Yanhui Cui,

Ying Wang,

Weizheng Kou,

Zhanhui Miao,

Ping Lü,

Lifang Wang,

XU Zhen-ye,

Fei Cao

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000475438

Subject(s) - bufalin , apoptosis , mg132 , downregulation and upregulation , cell growth , chemistry , cell , proteasome inhibitor , microbiology and biotechnology , cancer research , biology , biochemistry , gene

Mcl-1, an anti-apoptotic Bcl-2 family member, is often overexpressed in non-small cell lung cancer (NSCLC). Bufalin has been reported to induce apoptosis in various tumor cells. However, there is no report showing that bufalin could downregulate Mcl-1 expression in NSCLC.

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