Open AccessDegradation of Mcl-1 through GSK-3β Activation Regulates Apoptosis Induced by Bufalin in Non-Small Cell Lung Cancer H1975 Cells
Author(s) -
Xiaohong Kang,
Jing-Hang Zhang,
Zhang Qing-qin,
Yanhui Cui,
Ying Wáng,
Weizheng Kou,
Zhanhui Miao,
Ping Lü,
Lifang Wang,
Zhiyong Xu,
Fei Cao
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000475438
Subject(s) - bufalin , apoptosis , mg132 , downregulation and upregulation , cell growth , chemistry , cell , proteasome inhibitor , microbiology and biotechnology , cancer research , biology , biochemistry , gene
Mcl-1, an anti-apoptotic Bcl-2 family member, is often overexpressed in non-small cell lung cancer (NSCLC). Bufalin has been reported to induce apoptosis in various tumor cells. However, there is no report showing that bufalin could downregulate Mcl-1 expression in NSCLC.