Nicotinamide N-Methyltransferase Suppression Participates in Nickel-Induced Histone H3 Lysine9 Dimethylation in BEAS-2B Cells | Zendy

Qian Li | Zendy; Mindi He | Zendy; Lin Mao | Zendy; Xue Wang | Zendy; Yulin Jiang | Zendy; Min Li | Zendy; Yonghui Lu | Zendy; Zhengping Yu | Zendy; Zhou Zhou | Zendy

Open Access

Nicotinamide N-Methyltransferase Suppression Participates in Nickel-Induced Histone H3 Lysine9 Dimethylation in BEAS-2B Cells

Author(s) -

Qian Li,

Mindi He,

Lin Mao,

Xue Wang,

Yulin Jiang,

Min Li,

Yonghui Lu,

Zhengping Yu,

Zhou Zhou

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000475432

Subject(s) - nad+ kinase , chemistry , nicotinamide , methyltransferase , methylation , histone h3 , histone , microbiology and biotechnology , acetylation , dna methylation , biochemistry , gene expression , enzyme , biology , dna , gene

Nickel compounds are well-established human carcinogens with weak mutagenic activity. Histone methylation has been proposed to play an important role in nickel-induced carcinogenesis. Nicotinamide N-methyltransferase (NNMT) decreases histone methylation in several cancer cells by altering the cellular ratio of S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH). However, the role of NNMT in nickel-induced histone methylation remains unclear.

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