Open AccessBone Marrow–Derived Mononuclear Cell Therapy Accelerates Renal Ischemia-Reperfusion Injury Recovery by Modulating Inflammatory, Antioxidant and Apoptotic Related Molecules
Author(s) -
Felipe Mateus Ornellas,
Débora S. Ornellas,
Sabrina V. Martini,
Raquel Carvalho Castiglione,
G. Ventura,
Patrícia Rieken Macêdo Rocco,
Bianca Gutfilen,
Sérgio Augusto Lopes de Souza,
Christina Maeda Takiya,
Marcelo M. Morales
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000471866
Subject(s) - cytoprotection , renal ischemia , bone marrow , inflammation , medicine , kidney , apoptosis , reperfusion injury , peripheral blood mononuclear cell , ischemia , acute kidney injury , pharmacology , pathology , immunology , chemistry , oxidative stress , biochemistry , in vitro
We investigated the regenerative capacity of intravenous administration of bone marrow-derived mononuclear cells (BMMCs) in a rat model of bilateral renal ischemia/reperfusion (IR) injury and the involvement of inflammatory anti-inflammatory and other biological markers in this process.