Open AccessInterleukin-4 Induces CpG Site-Specific Demethylation of the Pendrin Promoter in Primary Human Bronchial Epithelial Cells
Author(s) -
Giada Scantamburlo,
Simone Vai,
Silvia Dossena,
Selma M. Soyal,
Emanuele Bernardinelli,
Davide Antonio Civello,
Wolfgang Patsch,
Markus Paulmichl,
Charity Nofziger
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000470720
Subject(s) - pendrin , cpg site , methylation , microbiology and biotechnology , dna methylation , messenger rna , stimulation , epigenetics , biology , demethylation , chemistry , gene expression , gene , endocrinology , biochemistry , transporter
Pendrin is upregulated in bronchial epithelial cells following IL-4 stimulation via binding of STAT6 to an N4 GAS motif. Basal CpG methylation of the pendrin promoter is cell-specific. We studied if a correlation exists between IL-4 sensitivity and the CpG methylation status of the pendrin promoter in human bronchial epithelial cell models.